Vitamin B12 and Parkinson's Disease

Posted by Daniel Patrick on

Parkinson's disease is a progressive neurodegenerative disease most often associated with motor dysfunction.  Symptoms of Parkinson's can increase fall risk which in turn increase risk for injury, hospitalization, disability, or death.

Low vitamin B12 levels are associated with Parkinson's patients. This correlation does not mean that vitamin B12 supplementation can prevent Parkinson's Disease. Though there does appear to be a meaningful relationship to the neurological function of B12 and it's participation in other physiological processes.

A recent write up in Mayo Clinic's journal reviews our current knowledge of the relationships mentioned above hoping to guide future research to investigate if and how B12 supplementation might be used therapeutically in combination with other established treatments to slow Parkinson's.

Vitamin B12 is just one part of a very complex puzzle involving B12, acetylcholine,  S-adenosylmethionine, and the SAM methylation cycle. 



McCarter, MD, S., Teigen, PHD, RD, L., McCarter, BS, A., Benarroch, MD, E., St. Louis, MD, MS, E. and Savica, MD, PHD, R. (2019). Low Vitamin B12 and Parkinson Disease: Potential Link to Reduced Cholinergic Transmission and Severity of Disease. [online] Mayoclinicproceedings.org. Available at: https://www.mayoclinicproceedings.org/article/S0025-6196(19)30177-6/pdf [Accessed 31 Jul. 2019].


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