Question In adults with type 2 diabetes, do vitamin D or omega-3 fatty acid supplements help prevent development or progression of kidney disease?
Findings In this 2 × 2 factorial randomized clinical trial that included 1312 participants with type 2 diabetes, there was no significant difference in the change in estimated glomerular filtration rate at 5 years with vitamin D3 supplementation vs placebo (−12.3 vs −13.1 mL/min/1.73 m2) or with omega-3 fatty acid supplementation vs placebo (−12.2 vs −13.1 mL/min/1.73 m2).
Meaning These findings do not support the use of vitamin D or omega-3 fatty acid supplementation for preserving kidney function in adults with type 2 diabetes.
de Boer IH, Zelnick LR, Ruzinski J, et al. Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial. JAMA. 2019;322(19):1899–1909. doi:https://doi.org/10.1001/jama.2019.17380